Intermolecular Interaction

Our research on intermolecular interaction centers on electronic structure calculation and analysis of molecular and crystal structures of organic molecules. As we know, many physicochemical properties of organic materials, including pharmaceutical compounds, are governed by intermolecular interactions. And these properties play critical roles in the stability and performance of...
read more

Molecular Packing and Crystal Structure-Property Relationship

Crystals are beautiful! It is equally fascinating to study them. For organic crystals, we are often mesmerized by the intricacy of the rich and unpredictable – at least for now – supramolecular tessellation sustained by intermolecular forces. The subtleties in strength and directionality of the intermolecular interactions are governed...
read more

Nucleation and Phase Transition

Crystallization of organic molecules, by and large, still remains as an art. Experiences and trials-and-errors are part of common practice. Unexpected appearance of polymorphs, failure to obtain a particular polymorph, concomitant polymorphs, process-induced phase transition, and difficulty to crystallize are just some typical challenges encountered in the manufacture of...
read more

Nanocrystal for Cancer Theranostics

For delivering poorly soluble anticancer agents, the current paradigm is to solubilize the drugs prior to the administration.  Our approach is to inject a drug as solid, crystalline particles of a few hundred nanometers without encapsulating and/or solubilizing chemicals and carriers.  Moreover, we have pioneered using hybrid nanocrystals to...
read more