Digital Human for Drug Development

DHD2 is a multi-scale and multi-level project to simulate and predict biotransport kinetics of drugs and drug dosage forms. It evolves from collaborations among researchers in pharmaceutics, pharmacy, biomedical sciences, and mechanical engineering at Purdue University, Korea Institute of Science and Technology (KIST), and Samsung Medical.

Digital Human for Drug Development

DHD2 is a multi-scale and multi-level project to simulate and predict biotransport kinetics of drugs and drug dosage forms. It evolves from collaborations among researchers in pharmaceutics, pharmacy, biomedical sciences, and mechanical engineering at Purdue University, Korea Institute of Science and Technology (KIST), and Samsung Medical.

NEWS

  • Second symposium will be held at Purdue

    The second symposium on DHD2 will be held at Purdue University on February 24-25, 2015. Visitors from KIST will join researchers at Purdue over a course of two days to formally kick off the grand effort of DHD2.

  • The group secured the first major funding

    The group led by Prof. Kinam Park, Showalter Distinguished Professor, from Industrial & Physical Pharmacy and Biomedical Engineering at Purdue University, secured their first major funding. It was contributed by Departments of Biomedical and Mechanical Engineering, KIST, and Samsung Medical. The funding will allow researchers at the three institutions to integrate their research efforts and develop computational and experimental prototypes on DHD2.

  • First symposium was held at Purdue

    The first symposium on DHD2 was held at Purdue University in August 2014. Researchers from Purdue and KIST presented their studies throughout the day. Fruitful discussion followed and it was agreed that further actions were needed to pursue funding and integrate individual efforts. It was organized by Prof. Kinam Park, Showalter Distinguished Professor, from Industrial & Physical Pharmacy and Biomedical Engineering at Purdue University. Speakers included Kinam Park (BME/IPPH), George Wodicka (BME), Kui Won Choi (KIST, Korea), Chansoo Kim (KIST, Korea), Tonglei Li (IPPH), Sara Quinney (IUSOM), Bumsoo Han (ME/BME), Tamara L Kinzer-Ursem (BME), Craig Goergen (BME), Sunil Prabhakar, Alan Qi, Voicu Popescu (Computer Sci), Jon Wright, and George Takahashi (Envision).

Bumsoo Han’s work highlighted

Bumsoo Han’s work highlighted

Mechanical Engineering, the official magazine of ASME (American Society of Mechanical Engineers), highlighted in the December issue of 2014 the research of Prof. Bumsoo Han, a DHD2 founding member from Purdue University. Dr. Han is a faculty member at Mechanical Engineering and his lab of Biotransport Phenomena has focused on developing chip-based devices called T-MOC (tumor-microenvironment-on-chip). The technology permits study of the microenvironment of tumor and local transport behaviors of potential anti-tumor therapeutic systems. An image of the article is attached... read more
Digital mouse being developed

Digital mouse being developed

A digital mouse model is being developed by Prof. Tonglei Li, a founding member of DHD2, in the Department of Industrial & Physical Pharmacy at Purdue University. The 3D model is physiologically accurate and capable of simulating and visualizing drug transport and pharmacokinetics of a drug delivery system. It serves as a guinea pig (!) for integrating various simulation methods and will pave the way for establishing the software architecture of DHD2. Below is a screen shot of the digital mouse showing a... read more

Who We Are

Kinam Park, Ph.D., School of Biomedical Engineering and Department of Industrial & Physical Pharmacy, Purdue University
Tonglei Li, Ph.D., Department of Industrial & Physical Pharmacy, Purdue University
George Wodicka, Ph.D., School of Biomedical Engineering, Purdue University
Bumsoo Han, Ph.D., School of Mechanical Engineering and School of Biomedical Engineering, Purdue University
Ick Chan Kwon, Ph.D., Korea Institute of Science and Technology
Kuiwon Choi, Ph.D., Korea Institute of Science and Technology
Sara Quinney, Ph.D., Indiana University School of Medicine
Chansoo Kim, Ph.D., Korea Institute of Science and Technology
Craig Goergen, Ph.D., School of Biomedical Engineering, Purdue University
Tamara L Kinzer-Ursem, Ph.D., School of Biomedical Engineering, Purdue University
Justin Seipel, Ph.D., School of Mechanical Engineering, Purdue University
Voicu Popescu, Ph.D., Department of Computer Sciences, Purdue University

Kangwon Lee, Ph.D., Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology
Minhee Park, Ph.D., Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology
Juhee Ryu, Ph.D., Korea Institute of Science and Technology
Soyoung Shin, Ph.D., Korea Institute of Science and Technology
Xiaohui Carol Song, Ph.D., Rosen Center for Advanced Computing, Purdue University
Ming-Tao Zhang, Ph.D., Department of Industrial & Physical Pharmacy, Purdue University
Seungman Park, Ph.D., School of Mechanical Engineering, Purdue University
Jayathi Murthy, Ph.D., Department of Mechanical Engineering, University of Texas at Austin
Yoon Yeo, Ph.D., Department of Industrial & Physical Pharmacy and School of Biomedical Engineering, Purdue University
Zhongming Liu, Ph.D., School of Biomedical Engineering and School of Electrical and Computer Engineering, Purdue University